Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
نویسندگان
چکیده
منابع مشابه
Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet.
Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early overnutrition permanently programs altered energy and glucose homeostasis. In the present studies, we used a mouse model to investigate whether early overnutrition increases susceptibility to obesity and insulin resistance in response to a high-fat diet (HFD). Litters from Swiss Webster dams were culled to...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2019
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci126107